Effect of telmisartan preventscerebral ischemia-reperfusion injury-mediated oxidative stress and inflammation in a rat model

With secure and dependable antihypertensive effects, telmisartan is an antihypertensive drug. Telmisartan was reported showing distinct neuroprotective effect in cerebral IR injury but the underlying mechanisms are still unclear. The aim of this study was to evaluate the effect of telmisartan prevents cerebral ischemia-reperfusion (I/R) injury-mediated oxidative stress and inflammation in model rat to explore possible molecular mechanism. Male Sprague-Dawley (SD) rats were used to induce cerebral I/R injury using middle cerebral artery occlusion. 30 SD rats were randomly and evenly divided into 3 groups: Sham, I/R, telmisartan treated ischemia-reperfusion group. The results showed that telmisartan improved neurological impairments, inhibited apoptosis, resisted oxidative stress and inflammation in hippocampus of cerebral I/R injury rats. However, pretreatment with telmisartan inhibited the activation of adrenocorticotropic hormone (ACTH), vasopressin, catecholamine and natriuretic peptides activities in cerebral IR injury rat. These findings confirm the involvement of telmisartan prevents cerebral ischemia-reperfusion injury-mediated oxidative stress and inflammation in model rat.